Congratulations to Zach Nevin for receiving the Cotterman Award for his paper "Modeling Mutations and Phenotypic Landscapes of Pelizaeus-Merzbacjer Disease with Human iPSC-Derived Oligodendrocytes AJHG 100: 617-34, April 2017"
Zach Nevin was also chosen as the director of the Trainee Board Member of the American Society for Human Genetics.

Daniel Factor defended his thesis title " Understanding epigenetic controllers of stem cell fate and function" and became the 4th PhD graduate from the Tesar Lab.

Zachary Nevin defended his Ph. D thesis titled "Modeling Genetic Diseases of Myelin Using Patient-Derived Induced Pluripotent Stem Cells". He now returns tp medical school to finish his MD training. We wish Zach all the best in his future.

Our newest paper on modeling Pelizaeus-Merzbacher Disease (PMD) is out today in the American Journal of Human Genetics. Lead author Zach Nevin generated panels of hiPSCs and oligodendrocytes from 12 PMD patients spanning the genetic and clinical diversity of PMD—including point mutations, duplications, triplication, and deletions of PLP1—and developed an in vitro platform for molecular and cellular characterization of all 12 mutations simultaneously. Identification of unique, as well as shared, defects in PLP1 mRNA expression and splicing, OPC development, oligodendrocyte morphology, and myelination from this study will facilitate personalized treatments in the future.

Access CWRU press release here
Access the paper here .

Congratulation to Tyler Miller of the Tesar and Rich Labs on defending his thesis "Identifying Novel in vivo Epigenetic Dependencies in Glioblastoma". We wish Dr.Miller the best of luck as he goes back to Medical School this summer to finish the second part of his MD/PhD.