Paul Tesar was selected as one of two recipients of the 2018 John S. Diekhoff Award for Mentoring. The annual award is presented to two faculty members who epitomize what it means to teach graduate students: to connect them with experts in their discipline, engage them academically in a forthright and collegial manner, and actively promote their professional development. One student award nominator wrote, “I want to be Paul when I become a faculty member myself, and it just isn’t his science … but his personal life and ability to balance the two…He is as good a mentor as he is a scientist.”

Read the Daily article here

Lucille was selected as one of two undergraduate students in the inaugural class of Beckman Scholars at CWRU. The prestigious undergraduate research grant and extensive mentorship was awarded for her research titled, “Investigating Methods and Mechanisms of Oligodendrocyte Restoration in Hypoxia-Induced White Matter Injury.”

Read the Daily article here

Paul Tesar, the Dr. Donald and Ruth Weber Goodman Professor of Innovative Therapeutics in the Department of Genetics and Genome Sciences at Case Western Reserve University School of Medicine, has been selected to receive the 2017 New York Stem Cell Foundation-Robertson Stem Cell Prize for his pioneering discovery of pluripotent epiblast stem cells and technologies to utilize pluripotent stem cells for discovery of new therapeutics for neurological disorders such as multiple sclerosis and pediatric leukodystrophies.

Read the NYSCF press release here
Read the CWRU press release

Congratulations to Zach Nevin for receiving the Cotterman Award for his paper "Modeling Mutations and Phenotypic Landscapes of Pelizaeus-Merzbacjer Disease with Human iPSC-Derived Oligodendrocytes AJHG 100: 617-34, April 2017"
Zach Nevin was also chosen as the director of the Trainee Board Member of the American Society for Human Genetics.

Daniel Factor defended his thesis title " Understanding epigenetic controllers of stem cell fate and function" and became the 4th PhD graduate from the Tesar Lab.

Zachary Nevin defended his Ph. D thesis titled "Modeling Genetic Diseases of Myelin Using Patient-Derived Induced Pluripotent Stem Cells". He now returns tp medical school to finish his MD training. We wish Zach all the best in his future.

Our newest paper on modeling Pelizaeus-Merzbacher Disease (PMD) is out today in the American Journal of Human Genetics. Lead author Zach Nevin generated panels of hiPSCs and oligodendrocytes from 12 PMD patients spanning the genetic and clinical diversity of PMD—including point mutations, duplications, triplication, and deletions of PLP1—and developed an in vitro platform for molecular and cellular characterization of all 12 mutations simultaneously. Identification of unique, as well as shared, defects in PLP1 mRNA expression and splicing, OPC development, oligodendrocyte morphology, and myelination from this study will facilitate personalized treatments in the future.

Access CWRU press release here
Access the paper here .