Our latest work has been published in Nature Communications "Rapid functional genetics of the oligodendrocyte lineage using pluripotent stem cells". Congratulations to Angela Lager and the entire team! The work demonstrates a highly efficient method for generating oligodendrocytes and their progenitors from mouse ES and iPS cells providing a rapid platform for genotype–phenotype interrogation in oligodendrocytes.

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Our latest work on Pelizaeus-Merzbacher disease has been published in Stem Cell Reports. Congratulations to Matthew Elitt and the entire team for their efforts. Their work demonstrates the power of stem cell biology to uncover new pathological phases in this pediatric disease. These findings will be critical for the development of comprehensive therapies for patients.

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We are proud to have collaborated with the Drew Adams lab on an exciting study published today in the journal Nature. The study defined a unifying mechanism by which small molecules stimulate the generation of new oligodendrocytes and enhance remyelination. This discovery will accelerate efforts to develop safe and effective medicines for patients with MS and other myelin disorders.

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Our latest paper is out today in the journal Nature Methods. Congratulations to Mayur Madhavan, Zach Nevin, and the entire team on developing a method to generate human brain tissue in the laboratory from any patient. These “oligocortical spheroids” now include oligodendrocytes allowing us to study human myelin development and disease in the lab for the first time.

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Paul Tesar was selected as one of two recipients of the 2018 John S. Diekhoff Award for Mentoring. The annual award is presented to two faculty members who epitomize what it means to teach graduate students: to connect them with experts in their discipline, engage them academically in a forthright and collegial manner, and actively promote their professional development. One student award nominator wrote, “I want to be Paul when I become a faculty member myself, and it just isn’t his science … but his personal life and ability to balance the two…He is as good a mentor as he is a scientist.”

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Congrats to Tyler who recently started as a Clinical Pathology Resident at Massachusetts General Hospital. Tyler received his MD and PhD through Case’s MSTP program and plans to continue his research on glioblastoma in Boston.

CWRU hosts an annual research competition for all Case undergraduates who have conducted research, which is biologically related. This year, Lili was selected as a finalist to give an oral presentation and won! Congrats Lili!