About the Tesar Lab

Research

Our laboratory sits at the interface between stem cell biology and developmental neuroscience. We use pluripotent stem cells to model neurological development and disease with a specific focus on glial cells in the central nervous system – oligodendrocytes and astrocytes. We are interested in the molecular mechanisms by which cells acquire glial fate and function during development and maintain their functionality throughout life. We leverage this knowledge to define the cellular and molecular dysfunction that underlies certain neurological diseases and strive to develop meaningful therapeutic interventions using high throughput chemical screening and other approaches.