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Paul Tesar receives Diekhoff Award for Mentoring

Paul Tesar was selected as one of two recipients of the 2018 John S. Diekhoff Award for Mentoring. The annual award is presented to two faculty members who epitomize what it means to teach graduate students: to connect them with experts in their discipline, engage them academically in a forthright and collegial manner, and actively promote their professional development. One student award nominator wrote, “I want to be Paul when I become a faculty member myself, and it just isn’t his science … but his personal life and ability to balance the two…He is as good a mentor as he is a scientist.”

Read the Daily article here

Lucille Hu selected as a Beckman Scholar

Lucille was selected as one of two undergraduate students in the inaugural class of Beckman Scholars at CWRU. The prestigious undergraduate research grant and extensive mentorship was awarded for her research titled, “Investigating Methods and Mechanisms of Oligodendrocyte Restoration in Hypoxia-Induced White Matter Injury.”

Read the Daily article here

Paul Tesar receives New York Stem Cell Foundation Robertson Stem Cell Prize

Paul Tesar, the Dr. Donald and Ruth Weber Goodman Professor of Innovative Therapeutics in the Department of Genetics and Genome Sciences at Case Western Reserve University School of Medicine, has been selected to receive the 2017 New York Stem Cell Foundation-Robertson Stem Cell Prize for his pioneering discovery of pluripotent epiblast stem cells and technologies to utilize pluripotent stem cells for discovery of new therapeutics for neurological disorders such as multiple sclerosis and pediatric leukodystrophies.

Read the NYSCF press release here
Read the CWRU press release

Dr. Nevin awarded Cotterman Award by the American Society for Human Genetics

Congratulations to Zach Nevin for receiving the Cotterman Award for his paper "Modeling Mutations and Phenotypic Landscapes of Pelizaeus-Merzbacjer Disease with Human iPSC-Derived Oligodendrocytes AJHG 100: 617-34, April 2017"
Zach Nevin was also chosen as the director of the Trainee Board Member of the American Society for Human Genetics.

Congratulations to Dr.Factor

Daniel Factor defended his thesis title " Understanding epigenetic controllers of stem cell fate and function" and became the 4th PhD graduate from the Tesar Lab.

Congratulations Dr.Nevin

Zachary Nevin defended his Ph. D thesis titled "Modeling Genetic Diseases of Myelin Using Patient-Derived Induced Pluripotent Stem Cells". He now returns tp medical school to finish his MD training. We wish Zach all the best in his future.

Modeling PMD

Our newest paper on modeling Pelizaeus-Merzbacher Disease (PMD) is out today in the American Journal of Human Genetics. Lead author Zach Nevin generated panels of hiPSCs and oligodendrocytes from 12 PMD patients spanning the genetic and clinical diversity of PMD—including point mutations, duplications, triplication, and deletions of PLP1—and developed an in vitro platform for molecular and cellular characterization of all 12 mutations simultaneously. Identification of unique, as well as shared, defects in PLP1 mRNA expression and splicing, OPC development, oligodendrocyte morphology, and myelination from this study will facilitate personalized treatments in the future.

Dr. Tesar at the University of Louisville

Dr. Tesar will present his seminar titled "“Molecular Control of Oligodendrocyte Progenitor Cell Fate and Function” at the Kentucky Spinal Cord Injury Research Center, University of Louisville.

Congratulation to Dr. Tyler Miller

Congratulation to Tyler Miller of the Tesar and Rich Labs on defending his thesis "Identifying Novel in vivo Epigenetic Dependencies in Glioblastoma". We wish Dr.Miller the best of luck as he goes back to Medical School this summer to finish the second part of his MD/PhD.

Existing drugs identified as potential MS treatments

Case Western Reserve scientists discovered that two common topical drugs appear to stimulate the production of oligodendrocytes to myelinate the central nervous system. The results of their investigation, published April 20, 2015 in Nature, give scientists cautious optimism that these drugs might effectively treat this disabling disease.

>> CLICK HERE to request more information or send comments to the research team

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