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Modeling PMD

Our newest paper on modeling Pelizaeus-Merzbacher Disease (PMD) is out today in the American Journal of Human Genetics. Lead author Zach Nevin generated panels of hiPSCs and oligodendrocytes from 12 PMD patients spanning the genetic and clinical diversity of PMD—including point mutations, duplications, triplication, and deletions of PLP1—and developed an in vitro platform for molecular and cellular characterization of all 12 mutations simultaneously. Identification of unique, as well as shared, defects in PLP1 mRNA expression and splicing, OPC development, oligodendrocyte morphology, and myelination from this study will facilitate personalized treatments in the future.

Congratulation to Dr. Tyler Miller

Congratulation to Tyler Miller of the Tesar and Rich Labs on defending his thesis "Identifying Novel in vivo Epigenetic Dependencies in Glioblastoma". We wish Dr.Miller the best of luck as he goes back to Medical School this summer to finish the second part of his MD/PhD.

Existing drugs identified as potential MS treatments

Case Western Reserve scientists discovered that two common topical drugs appear to stimulate the production of oligodendrocytes to myelinate the central nervous system. The results of their investigation, published April 20, 2015 in Nature, give scientists cautious optimism that these drugs might effectively treat this disabling disease.

>> CLICK HERE to request more information or send comments to the research team

Paul Tesar named Outstanding Young Investigator!

The International Society for Stem Cell Research (ISSCR) has named Paul Tesar Ph.D. of Case Western Reserve University the Outstanding Young Investigator for 2015. The award “recognizes the exceptional achievements of an investigator in the early part of his or her independent career in stem cell research who will be honored with the award at the ISSCR Annual Meeting in Stockholm, Sweden in June 2015.”

Dr. Tesar joins the ranks of previous winners Valentina Greco (Yale University), Marius Wernig (Stanford University), Cédric Blanpain (Université Libre De Bruxelles), Robert Blelloch (University of California, San Francisco), Joanna Wysocka (Stanford University) and Konrad Hochedlinger (Harvard University). The award reflects not only the caliber of Dr. Tesar’s work, but also the caliber of the stem cell community in Cleveland, Ohio.

Discovery of "Seed" Enhancers

Check out our newest publication in Cell Stem Cell on the discovery of "Seed" Enhancers and their role in pluripotent stem cells!

The finding stemmed from a synergy between the Tesar Laboratory's expertise in embryonic and epiblast stem cells and the genomics expertise of the Scacheri Laboratory. Both laboratories are part of the Genetics and Genome Sciences Department of Case Western Reserve University, Cleveland Ohio.

Congratulations to co-first authors Daniel Factor and Olivia Corradin!

Click Here for the press release.

Click Here for the article.

Paul Tesar awarded the Dr. Donald and Ruth Weber Goodman Professor of Innovative Therapeutics

Cleveland area philanthropists Dr. Donald and Ruth Weber Goodman had a historic commitment to Research and Case Western Reserve University. Their outstanding generosity has supported education and research programs at the schools of medicine and dental medicine. Furthermore they have established two professorships, one of which was awarded to Paul Tesar.

Paul Tesar and the Tesar Lab sincerely thank the Goodman family for their support of our research and continued support of Case Western Reserve University!

Tesar Lab awarded new grant from NINDS to advance novel therapeutics for multiple sclerosis

The Tesar Lab was recently awarded a grant from the National Institute of Neurological Disorders and Stroke to advance therapeutics for multiple sclerosis. The Tesar Lab's expertise in stem cell biology and high throughput screening provides a unique opportunity to discover innovative therapeutics that could halt devastating diseases.

Discovery of Induced-Oligodendrocyte Progenitors holds great promise for Medicine

Oligodendrocytes are the cell-type responsible for myelinating neurons of the brain. In myelin diseases, such as Multiple Sclerosis and Cerebral Palsy, oligodendrocytes are destroyed causing severe disability in patients. Researchers are desperate to understand disease pathology and also to develop cell transplantation therapies. However efforts have been largely hindered by limited access to oligodendrocytes.

The Tesar Lab has unlocked the potential to produce oligodendrocyte progenitors through a novel technique. This technique, published in Nature Biotechnology, involves directly converting fibroblasts into oligodendrocyte progenitors.

Tesar Lab Graduate Student Zachary Nevin Awarded Project Grant from the PMD Foundation

The PMD Foundation is an organization focused on serving those affected with Pelizaeus Merzbacher Disease (PMD). Click Here for more information.

MD/PhD student Zachary Nevin was awarded the James Y Garbern Research Project Grant to conduct his work on PMD patient specific induced pluripotent stem cell lines. Click Here for the press release.

Are Online Classes the Wave of the Future?

The internet has provided a conduit for the world to be connected. Pictures, videos, feelings, and ideas can be communicated instantly with the touch of a screen.

With these means of communication emerging at supersonic pace and reaching unprecedented numbers of people, it is up to us to ensure that the content we distribute is of high quality and improves our lives.

Paul Tesar was recently filmed in a RENEW online course. The RENEW initiative is focused on collecting videotaped courses and sharing these courses with students all over the world. Paul was elated to be part of the initiative by sharing his session on reprogramming technology. Paul hopes to make contagious his passion for science and inspire the next generation of scientists.

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