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Paul Tesar receives New York Stem Cell Foundation Robertson Stem Cell Prize

Paul Tesar, the Dr. Donald and Ruth Weber Goodman Professor of Innovative Therapeutics in the Department of Genetics and Genome Sciences at Case Western Reserve University School of Medicine, has been selected to receive the 2017 New York Stem Cell Foundation-Robertson Stem Cell Prize for his pioneering discovery of pluripotent epiblast stem cells and technologies to utilize pluripotent stem cells for discovery of new therapeutics for neurological disorders such as multiple sclerosis and pediatric leukodystrophies.

Read the NYSCF press release here
Read the CWRU press release

Dr. Nevin awarded Cotterman Award by the American Society for Human Genetics

Congratulations to Zach Nevin for receiving the Cotterman Award for his paper "Modeling Mutations and Phenotypic Landscapes of Pelizaeus-Merzbacjer Disease with Human iPSC-Derived Oligodendrocytes AJHG 100: 617-34, April 2017"
Zach Nevin was also chosen as the director of the Trainee Board Member of the American Society for Human Genetics.

Congratulations to Dr.Factor

Daniel Factor defended his thesis title " Understanding epigenetic controllers of stem cell fate and function" and became the 4th PhD graduate from the Tesar Lab.

Congratulations Dr.Nevin

Zachary Nevin defended his Ph. D thesis titled "Modeling Genetic Diseases of Myelin Using Patient-Derived Induced Pluripotent Stem Cells". He now returns tp medical school to finish his MD training. We wish Zach all the best in his future.

Modeling PMD

Our newest paper on modeling Pelizaeus-Merzbacher Disease (PMD) is out today in the American Journal of Human Genetics. Lead author Zach Nevin generated panels of hiPSCs and oligodendrocytes from 12 PMD patients spanning the genetic and clinical diversity of PMD—including point mutations, duplications, triplication, and deletions of PLP1—and developed an in vitro platform for molecular and cellular characterization of all 12 mutations simultaneously. Identification of unique, as well as shared, defects in PLP1 mRNA expression and splicing, OPC development, oligodendrocyte morphology, and myelination from this study will facilitate personalized treatments in the future.

Congratulation to Dr. Tyler Miller

Congratulation to Tyler Miller of the Tesar and Rich Labs on defending his thesis "Identifying Novel in vivo Epigenetic Dependencies in Glioblastoma". We wish Dr.Miller the best of luck as he goes back to Medical School this summer to finish the second part of his MD/PhD.

Existing drugs identified as potential MS treatments

Case Western Reserve scientists discovered that two common topical drugs appear to stimulate the production of oligodendrocytes to myelinate the central nervous system. The results of their investigation, published April 20, 2015 in Nature, give scientists cautious optimism that these drugs might effectively treat this disabling disease.

>> CLICK HERE to request more information or send comments to the research team

Paul Tesar named Outstanding Young Investigator!

The International Society for Stem Cell Research (ISSCR) has named Paul Tesar Ph.D. of Case Western Reserve University the Outstanding Young Investigator for 2015. The award “recognizes the exceptional achievements of an investigator in the early part of his or her independent career in stem cell research who will be honored with the award at the ISSCR Annual Meeting in Stockholm, Sweden in June 2015.”

Dr. Tesar joins the ranks of previous winners Valentina Greco (Yale University), Marius Wernig (Stanford University), Cédric Blanpain (Université Libre De Bruxelles), Robert Blelloch (University of California, San Francisco), Joanna Wysocka (Stanford University) and Konrad Hochedlinger (Harvard University). The award reflects not only the caliber of Dr. Tesar’s work, but also the caliber of the stem cell community in Cleveland, Ohio.

Discovery of "Seed" Enhancers

Check out our newest publication in Cell Stem Cell on the discovery of "Seed" Enhancers and their role in pluripotent stem cells!

The finding stemmed from a synergy between the Tesar Laboratory's expertise in embryonic and epiblast stem cells and the genomics expertise of the Scacheri Laboratory. Both laboratories are part of the Genetics and Genome Sciences Department of Case Western Reserve University, Cleveland Ohio.

Congratulations to co-first authors Daniel Factor and Olivia Corradin!

Click Here for the press release.

Click Here for the article.

Paul Tesar awarded the Dr. Donald and Ruth Weber Goodman Professor of Innovative Therapeutics

Cleveland area philanthropists Dr. Donald and Ruth Weber Goodman had a historic commitment to Research and Case Western Reserve University. Their outstanding generosity has supported education and research programs at the schools of medicine and dental medicine. Furthermore they have established two professorships, one of which was awarded to Paul Tesar.

Paul Tesar and the Tesar Lab sincerely thank the Goodman family for their support of our research and continued support of Case Western Reserve University!

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