Directed Differentiation of Pluripotent Stem Cells to Oligodendrocytes

Check out our recently published paper in Nature Methods: "Rapid and robust generation of functional oligodendrocyte progenitor cells from epiblast stem cells"

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Click Here for the CWRU press release.

Oligodendrocytes are critical to the formation of myelin in the central nervous system. Defects in myelination are implicated in many neurodegenerative diseases such as Multiple Sclerosis, Cerebral Palsy, and the Leukodystrophies. Stem cells provide a promising means to understand disease pathways and also provide the powerful possibility to therapeutically treat them. In this study we demonstrated a platform for the effective and robust production of functional oligodendrocytes from pluripotent stem cells. These oligodendrocytes are a priceless resource to discovering powerful therapeutics that will treat and possibly cure myelin disorders.

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