Publications

2018 2018

Lager AM, Corradin OG, Cregg JM, Elitt MS, Shick HE, Clayton BLL, Allan KC, Olsen HE, Madhavan M, Tesar PJ.

Rapid functional genetics of the oligodendrocyte lineage using pluripotent stem cells.

Nature Communications. 2018 Sep 13;9(1):3708. doi: 10.1038/s41467-018-06102-7. PubMed PMID: 30213958.

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Elitt MS, Shick HE, Madhavan M, Allan KC, Clayton BLL, Weng C, Miller TE, Factor DC, Barbar L, Nawash BS, Nevin ZS, Lager AM, Li Y, Jin F, Adams DJ, Tesar PJ.

Chemical Screening Identifies Enhancers of Mutant Oligodendrocyte Survival and Unmasks a Distinct Pathological Phase in Pelizaeus-Merzbacher Disease.

Stem Cell Reports. 2018 Aug 23. pii: S2213-6711(18)30320-5. doi: 10.1016/j.stemcr.2018.07.015. [Epub ahead of print] PubMed PMID: 30146490.

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Elitt MS, Barbar L, Tesar PJ.

Drug screening for human genetic diseases using iPSC models.
Human Molecular Genetics.

2018 Aug 1;27(R2):R89-R98. doi: 10.1093/hmg/ddy186. PubMed PMID: 29771306; PubMed Central PMCID: PMC6061782.

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Hubler Z, Allimuthu D, Bederman I, Elitt MS, Madhavan M, Allan KC, Shick HE, Garrison E, T Karl M, Factor DC, Nevin ZS, Sax JL, Thompson MA, Fedorov Y, Jin J, Wilson WK, Giera M, Bracher F, Miller RH, Tesar PJ, Adams DJ.

Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination.

Nature. 2018 Aug;560(7718):372-376. doi: 10.1038/s41586-018-0360-3. Epub 2018 Jul 25. PubMed PMID: 30046109.

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Madhavan M, Nevin ZS, Shick HE, Garrison E, Clarkson-Paredes C, Karl M, Clayton BLL, Factor DC, Allan KC, Barbar L, Jain T, Douvaras P, Fossati V, Miller RH, Tesar PJ.

Induction of myelinating oligodendrocytes in human cortical spheroids.

Nat Methods. 2018 Sep;15(9):700-706. doi: 10.1038/s41592-018-0081-4. Epub 2018 Jul 25. PubMed PMID: 30046099.

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Chai S, Wan X, Ramirez-Navarro A, Tesar PJ, Kaufman ES, Ficker E, George AL Jr., Deschênes I.

Physiological genomics identifies genetic modifiers of long QT syndrome type 2 severity.

J Clin Invest. 2018 Mar 1;128(3):1043-1056. doi: 10.1172/JCI94996. Epub 2018 Feb 12. PubMed PMID: 29431731.

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2017 2017

Scacheri PC, Tesar PJ.

iPSC Reprogramming Is Not Just an Open and Shut Case.

Cell Stem Cell. 2017 Dec 7;21(6):711-712. doi: 10.1016/j.stem.2017.11.017. PubMed PMID: 29220662.

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Cohen JA, Tesar PJ.

Clemastine fumarate for promotion of optic nerve remyelination.

Lancet. 2017 Dec 2;390(10111):2421-2422. doi: 10.1016/S0140-6736(17)32639-9. Epub 2017 Oct 10. PubMed PMID: 29029894.

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Scolding NJ, Pasquini M, Reingold SC, Cohen JA and the Cell-Based Therapies for Multiple Sclerosis Working Group [Atkins H, Banwell B, Bar-Or A, Bebo B, Bowen J, Burt R, Calabresi P, Cohen J, Comi G, Connick P, Cross A, Cutter G, Derfuss T, Ffrench-Constant C, Freedman M, Galipeau J, Goldman M, Goldman S, Goodman A, Green A, Griffith L, Hartung HP, Hemmer B, Hyun I, Iacobaeus E, Inglese M, Jubelt B, Karussis D, Küry P, Landsman D, Laule C, Liblau R, Mancardi G, Marrie RA, Miller A, Miller R, Miller D, Mowry E, Muraro P, Nash R, Ontaneda D, Pasquini M, Pelletier D, Peruzzotti-Jametti L, Pluchino S, Racke M, Reingold S, Rice C, Ringdén O, Rovira A, Saccardi R, Sadiq S, Sarantopoulos S, Savitz S, Scolding N, Soelberg Sorensen P, Pia Sormani M, Stuve O, Tesar P, Thompson A, Trojano M, Uccelli A, Uitdehaag B, Utz U, Vukusic S, Waubant E, Wilkins A]

Cell-based therapeutic strategies for multiple sclerosis.

Brain. 2017 Nov 1;140(11):2776-2796. doi: 10.1093/brain/awx154. Review. PubMed PMID: 29053779.

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Windrem MS, Osipovitch M, Liu Z, Bates J, Chandler-Militello D, Zou L, Munir J, Schanz S, McCoy K, Miller RH, Wang S, Nedergaard M, Findling RL, Tesar PJ, Goldman SA.

Human iPSC glial mouse chimeras reveal glial contributions to schizophrenia.

Cell Stem Cell. 2017 Aug 3;21(2):195-208.e6. doi: 10.1016/j.stem.2017.06.012. Epub 2017 Jul 20. PubMed PMID: 28736215; PubMed Central PMCID: PMC5576346.

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Miller TE, Liau BB, Wallace LC, Morton AR, Xie Q, Dixit D, Factor DC, Kim LJY, Morrow JJ, Wu Q, Mack SC, Hubert CG, Gillespie SM, Flavahan WA, Hoffmann T, Thummalapalli R, Hemann MT, Paddison PJ, Horbinski CM, Zuber J, Scacheri PC, Bernstein BE, *Tesar PJ, *Rich JN.

Transcription elongation factors represent in vivo cancer dependencies in glioblastoma.

Nature. 2017 Jul 5. doi:10.1038/nature23000. [Epub ahead of print] PubMed PMID: 28678782. *co-senior author

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Somoza RA, Correa D, Labat I, Sternberg H, Forrest ME, Khalil AM, West MD, Tesar PJ, Caplan AI.

Transcriptome-wide analyses of human neonatal articular cartilage and human mesenchymal stem cells (hMSCs)-derived cartilage provide a new molecular target for evaluating engineered cartilage.

Tissue Engineering Part A. 2017 Jun 10. doi: 10.1089/ten.TEA.2016.0559. [Epub ahead of print] PubMed PMID: 28602122.

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Karl R, Lager A, Najm F, Tesar P.J.

Reprogramming of Mouse Fibroblasts to Induced Oligodendrocyte Progenitor Cells.

Vol. 126, Stem Cell Technologies in Neuroscience, Neuromethods (Springer). p79-94. ISBN: 978-1-4939-7022-3, DOI:10.1007/978-1-7024-7_5.

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Nevin ZS, Factor DC, Karl RT, Douvaras P, Laukka J, Windrem MS, Goldman SA, Fossati V, Hobson GM, Tesar PJ

Modeling the Mutational and Phenotypic Landscapes of Pelizaeus-Merzbacher Disease with Human iPSC-Derived Oligodendrocytes.

Am J Hum Genet. 2017 Apr 6;100(4):617-634. doi:10.1016/j.ajhg.2017.03.005. Epub 2017 Mar 30. PubMed PMID: 28366443; PubMed Central PMCID: PMC5384098.

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Osorio MJ, Rowitch DH, Tesar P, Wernig M, Windrem MS, Goldman SA.

Concise Review: Stem Cell-Based Treatment of Pelizaeus-Merzbacher Disease.

Stem Cells. 2017 Feb;35(2):311-315. doi: 10.1002/stem.2530. Epub 2016 Nov 23. Review. PubMed PMID: 27882623; PubMed Central PMCID: PMC5314962.

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2016 2016

Benner B, Martorell AJ, Mahadevan P, Najm FJ, Tesar P.J., Freundt EC.

Depletion of Olig2 in oligodendrocyte progenitor cells infected by Theiler's murine encephalomyelitis virus.

J Neurovirol. 2016 Dec 2. [Epub ahead of print] PubMed PMID: 26631080.

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Sheng Y, Filichia E, Shick E, Preston KL, Phillips KA, Cooperman L, Lin Z, Tesar P.J., Hoffer B, Luo Y.

Using iPSC-derived human DA neurons from opioid-dependent subjects to study dopamine dynamics.

Brain Behav. 2016 May 25;6(8):e00491. doi: 10.1002/brb3.491. PubMed PMID: 27547496; PubMed Central PMCID: PMC4884574.

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Sheng Y, Filichia E, Shick E, Preston KL, Phillips KA, Cooperman L, Lin Z, Tesar P.J., Hoffer BJ, Luo Y.

Lower Dopamine D2 Receptor Expression Levels in Human Dopaminergic Neurons Derived From Opioid-Dependent iPSCs

Am J Psychiatry. 2016 Apr 1;173(4):429-31. doi: 10.1176/appi.ajp.2015.15121545. PubMed PMID: 27035534.

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Tesar, P.J.

Snapshots of Pluripotency.

Stem Cell Reports. 2016 Feb 9;6(2):163-7. doi: 10.1016/j.stemcr.2015.12.011. Epub 2016 Jan 28. Review. PubMed PMID: 26833092; PubMed Central PMCID: PMC4750095.

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2015 2015

Schonberg DL, Miller TE, Wu Q, Flavahan WA, Das NK, Hale JS, Hubert CG, Mack SC, Jarrar AM, Karl RT, Rosager AM, Nixon AM, Tesar P.J., Hamerlik P, Kristensen BW, Horbinski C, Connor JR, Fox PL, Lathia JD, Rich JN.

Preferential Iron Trafficking Characterizes Glioblastoma Stem-like Cells

Cancer Cell. 2015 Oct 12;28(4):441-55. doi: 10.1016/j.ccell.2015.09.002. PubMed PMID: 26461092; PubMed Central PMCID: PMC4646058.

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Najm, F., Madhavan, M., Zaremba, A., Shick, E., Karl, R., Factor, D., Miller, T., Nevin, Z., Kantor, C., Sargent, A., Quick, K., Schlatzer, D., Tang, H., Papoian, R., Brimacombe, K., Shen, M., Boxer, M., Jadhav, A., Robinson, A., Podojil, J., Miller, S., Miller, R., and Tesar, P.J.

Drug-Based Modulation of Endogenous Stem Cells Promotes Functional Remyelination in Vivo

Nature. 2015 Jun 11;522(7555):216-20. doi: 10.1038/nature14335.

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Tesar, P.J.

Boosting our brains.

Science Translational Medicine. 4 March 2015 7:277ec38. DOI:10.1126/scitranslmed.aaa9498.

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Tesar, P.J.

Stem cell transplants may HALT multiple sclerosis.

Science Translational Medicine. 21 January 2015 7:271ec13. DOI:10.1126/scitranslmed.aaa6672.

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2014 2014

Miller, T., Wang, J., Sukhdeo, K., Horbinski, C., Tesar, P.J., Wechsler-Reya, R., and Rich, J.

Lgr5 Marks Post-Mitotic, Lineage Restricted Cerebellar Granule Neurons during Postnatal Development

PLoS One. 2014 Dec 10;9(12):e114433. doi:10.1371/journal.pone.0114433. PubMed PMID: 25493560.

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Tesar, P.J.

Morphing Cell Identity to Treat Diabetes

Science Translational Medicine Dec 3;6(265):265ec208. (2014)

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Tesar, P.J.

Stem Cell Therapy for Diabetes Comes of Age

Science Translational Medicine Oct 22;6(259):259ec182. (2014)

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Tesar, P.J.

Two Paths Diverged in a Schwann Cell

Science Translational Medicine Sept 10;6(253):253ec157. (2014)

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Tesar, P.J.

A Pillar of Hope for New Multiple Sclerosis Therapeutics

Science Translational Medicine July 30;6(247):247ec132. (2014)

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Tesar, P.J.

Power of the Young—New Stem Cell Source for Treating Autoimmune Disease

Science Translational Medicine June 18;6(241):241ec107. (2014)

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Factor DC, Corradin O, Zentner GE, Saiakhova A, Song L, Chenoweth JG, McKay RD, Crawford GE, Scacheri PC, Tesar PJ.

Epigenomic Comparison Reveals Activation of "Seed" Enhancers during Transition from Naive to Primed Pluripotency.

Cell Stem Cell. 2014 Jun 5;14(6):854-63. doi: 10.1016/j.stem.2014.05.005

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Tesar, P.J.

Somatic Cell Nuclear Transfer Is All Grown Up

Science Translational Medicine May 7;6(235):235ec82. (2014)

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Boles NC, Hirsch SE, Le S, Corneo B, Najm F, Minotti AP, Wang Q, Lotz S, Tesar PJ, Fasano CA.

NPTX1 regulates neural lineage specification from human pluripotent stem cells.

Cell Rep. 2014 Feb 27;6(4):724-36. doi: 10.1016/j.celrep.2014.01.026. Epub 2014 Feb 13.

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Tesar, P.J.

Monkeying Around with the Genome

Science Translational Medicine Mar 26;6(229):229ec56. (2014)

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Ware CB, Nelson AM, Mecham B, Hesson J, Zhou W, Jonlin EC, Jimenez-Caliani AJ, Deng X, Cavanaugh C, Cook S, Tesar PJ, Okada J, Margaretha L, Sperber H, Choi M, Blau CA, Treuting PM, Hawkins RD, Cirulli V, Ruohola-Baker H.

Derivation of naive human embryonic stem cells.

Proc Natl Acad Sci U S A. 2014 Mar 25;111(12):4484-9. doi: 10.1073/pnas.1319738111. Epub 2014 Mar 12.

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2013 2013

Maeda T, Lee MJ, Palczewska G, Marsili S, Tesar PJ, Palczewski K, Takahashi M, Maeda A.

Retinal pigmented epithelial cells obtained from human induced pluripotent stem cells possess functional visual cycle enzymes in vitro and in vivo.

J Biol Chem. 2013 Nov 29;288(48):34484-93. doi: 10.1074/jbc.M113.518571. Epub 2013 Oct 15.

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Tesar, P.J

Crowdsourcing science

Cell Stem Cell. Nov 7;13(5):517.

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Factor, D., Tesar, P.J., and Khalil, A.

Chromatin regulation by long non-coding RNAs.

In Molecular Biology of Long Non-coding RNAs. pp1-13. New York, NY. Springer.

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Factor DC, Najm FJ, Tesar PJ.

Generation and characterization of epiblast stem cells from blastocyst-stage mouse embryos.

Methods Mol Biol. 2013;1074:1-13. doi: 10.1007/978-1-62703-628-3_1.

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Najm FJ, Lager AM, Zaremba A, Wyatt K, Caprariello AV, Factor DC, Karl RT, Maeda T, Miller RH, Tesar PJ

Transcription factor-mediated reprogramming of fibroblasts to expandable, myelinogenic oligodendrocyte progenitor cells

Nat Biotechnol. 2013 Apr 14. doi: 10.1038/nbt.2561. [Epub ahead of print]

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Park KS, Cha Y, Kim CH, Ahn HJ, Kim D, Ko S, Kim KH, Chang MY, Ko JH, Noh YS, Han YM, Kim J, Song J, Kim JY, Tesar PJ, Lanza R, Lee KA, Kim KS

Transcription elongation factor Tcea3 regulates the pluripotent differentiation potential of mouse embryonic stem cells via the Lefty1-Nodal-Smad2 pathway

Stem Cells. 2013 Feb;31(2):282-92. doi: 10.1002/stem.1284

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Mallon BS, Chenoweth JG, Johnson KR, Hamilton RS, Tesar PJ, Yavatkar AS, Tyson LJ, Park K, Chen KG, Fann YC, McKay RD

StemCellDB: the human pluripotent stem cell database at the National Institutes of Health

Stem Cell Res. 2013 Jan;10(1):57-66. doi: 10.1016/j.scr.2012.09.002

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2012 2012

Iwafuchi-Doi M, Matsuda K, Murakami K, Niwa H, Tesar PJ, Aruga J, Matsuo I, Kondoh H

Transcriptional regulatory networks in epiblast cells and during anterior neural plate development as modeled in epiblast stem cells

Development. 2012 Nov;139(21):3926-37. doi: 10.1242/dev.085936

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Song J, Saha S, Gokulrangan G, Tesar PJ, Ewing RM

DNA and Chromatin Modification Networks Distinguish Stem Cell Pluripotent Ground States

Mol Cell Proteomics. 2012 Jul 22. [Epub ahead of print]

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Nelson VR, Heaney JD, Tesar PJ, Davidson NO, Nadeau JH

Transgenerational epigenetic effects of the Apobec1 cytidine deaminase deficiency on testicular germ cell tumor susceptibility and embryonic viability

Proc Natl Acad Sci U S A. 2012 Aug 24. [Epub ahead of print]

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Akhtar-Zaidi B, Cowper-Sal Lari R, Corradin O, Saiakhova A, Bartels CF, Balasubramanian D, Myeroff L, Lutterbaugh J, Jarrar A, Kalady MF, Willis J, Moore JH, Tesar PJ, Laframboise T, Markowitz S, Lupien M, Scacheri PC

Epigenomic Enhancer Profiling Defines a Signature of Colon Cancer

Science. 2012 Apr 12. [Epub ahead of print]

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De Los Angeles A, Loh YH, Tesar PJ, Daley GQ

Accessing naïve human pluripotency

Curr Opin Genet Dev. 2012 Mar 29. [Epub ahead of print]

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2011 2011

Miller RH, Tesar PJ

Tracking down the human myelinating cell

Nat Biotechnol; 2011, Oct 13; 29(10):881-3

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Hyun I, Tesar P

Stem cells: Cloning advance calls for careful regulation

Nature; 2011, Oct 5; 478(7367):36-7

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Najm FJ, Zaremba A, Caprariello AV, Nayak S, Freundt EC, Scacheri PC, Miller RH, Tesar PJ

Rapid and robust generation of functional oligodendrocyte progenitor cells from epiblast stem cells

Nat Methods; 2011, Sep 25

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Zentner GE, Tesar PJ, Scacheri PC

Epigenetic signatures distinguish multiple classes of enhancers with distinct cellular functions

Genome Res; 2011, Aug 1

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Najm FJ, Chenoweth JG, Anderson PD, Nadeau JH, Redline RW, McKay RD, Tesar PJ

Isolation of epiblast stem cells from preimplantation mouse embryos

Cell Stem Cell; 2011, Mar 4; 8(3):318-25

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2010 2010

Chenoweth JG, Tesar PJ

Isolation and maintenance of mouse epiblast stem cells

Methods Mol Biol; 2010, Dec 31; 636:25-44

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Di Stefano B, Buecker C, Ungaro F, Prigione A, Chen HH, Welling M, Eijpe M, Mostoslavsky G, Tesar P, Adjaye J, Geijsen N, Broccoli V

An ES-like pluripotent state in FGF-dependent murine iPS cells

PLoS One; 2010, Dec 30; 5(12):e16092

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Zentner GE, Hurd EA, Schnetz MP, Handoko L, Wang C, Wang Z, Wei C, Tesar PJ, Hatzoglou M, Martin DM, Scacheri PC

CHD7 functions in the nucleolus as a positive regulator of ribosomal RNA biogenesis

Hum Mol Genet; 2010, Sep 15, 19(18):3491-501

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Schnetz MP, Handoko L, Akhtar-Zaidi B, Bartels CF, Pereira CF, Fisher AG, Adams DJ, Flicek P, Crawford GE, Laframboise T, Tesar P, Wei CL, Scacheri PC

CHD7 targets active gene enhancer elements to modulate ES cell-specific gene expression

PLoS Genet; 2010, Jul 15; 6(7):e1001023

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Hemberger M, Udayashankar R, Tesar P, Moore H, Burton GJ

ELF5-enforced transcriptional networks define an epigenetically regulated trophoblast stem cell compartment in the human placenta

Hum Mol Genet; 2010, Jun 15

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Chenoweth JG, McKay RD, Tesar PJ

Epiblast stem cells contribute new insight into pluripotency and gastrulation

Dev Growth Differ; 2010, Apr 1

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Greber B, Wu G, Bernemann C, Joo JY, Han DW, Ko K, Tapia N, Sabour D, Sterneckert J, Tesar P, Schöler HR

Conserved and Divergent Roles of FGF Signaling in Mouse Epiblast Stem Cells and Human Embryonic Stem Cells

Cell Stem Cell; 2010, Mar 5; 6(3):215-226

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2009 2009

Anderson PD, Nelson VR, Tesar PJ, Nadeau JH

Genetic Factors on Mouse Chromosome 18 Affecting Susceptibility to Testicular Germ Cell Tumors and Permissiveness to Embryonic Stem Cell Derivation

Cancer Res; 2009, Dec 1

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2008 2008

Chou YF, Chen HH, Eijpe M, Yabuuchi A, Chenoweth JG, Tesar P, Lu J, McKay RD, Geijsen N

The growth factor environment defines distinct pluripotent ground states in novel blastocyst-derived stem cells

Cell; 2008, Oct 31; 135(3):449-61

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2007 2007

Xi H, Shulha HP, Lin JM, Vales TR, Fu Y, Bodine DM, McKay RD, Chenoweth JG, Tesar PJ, Furey TS, Ren B, Weng Z, Crawford GE

Identification and characterization of cell type-specific and ubiquitous chromatin regulatory structures in the human genome

PLoS Genet;2007, Aug 28; 3(8):e136

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Tesar PJ, Chenoweth JG, Brook FA, Davies TJ, Evans EP, Mack DL, Gardner RL, McKay RD

New cell lines from mouse epiblast share defining features with human embryonic stem cells

Nature; 2007, Jul 12; 448(7150):196-9

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2006 2006

Mackay DL, Tesar PJ, Liang LN, Haynesworth SE

Characterizing medullary and human mesenchymal stem cell-derived adipocytes

J Cell Physiol;2006 Jun 2; 207(3):722-8

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2005 2005

Tesar PJ

Derivation of germ-line-competent embryonic stem cell lines from preblastocyst mouse embryos

Proc Natl Acad Sci U S A; 2005, Jun 7; 102(23):8239-44

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