Publications

2014 2014

Factor DC, Corradin O, Zentner GE, Saiakhova A, Song L, Chenoweth JG, McKay RD, Crawford GE, Scacheri PC, Tesar PJ.

Epigenomic Comparison Reveals Activation of "Seed" Enhancers during Transition from Naive to Primed Pluripotency.

Cell Stem Cell. 2014 Jun 5;14(6):854-63. doi: 10.1016/j.stem.2014.05.005

Link to Publication: Click Here

Boles NC, Hirsch SE, Le S, Corneo B, Najm F, Minotti AP, Wang Q, Lotz S, Tesar PJ, Fasano CA.

NPTX1 regulates neural lineage specification from human pluripotent stem cells.

Cell Rep. 2014 Feb 27;6(4):724-36. doi: 10.1016/j.celrep.2014.01.026. Epub 2014 Feb 13.

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Ware CB, Nelson AM, Mecham B, Hesson J, Zhou W, Jonlin EC, Jimenez-Caliani AJ, Deng X, Cavanaugh C, Cook S, Tesar PJ, Okada J, Margaretha L, Sperber H, Choi M, Blau CA, Treuting PM, Hawkins RD, Cirulli V, Ruohola-Baker H.

Derivation of naive human embryonic stem cells.

Proc Natl Acad Sci U S A. 2014 Mar 25;111(12):4484-9. doi: 10.1073/pnas.1319738111. Epub 2014 Mar 12.

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2013 2013

Maeda T, Lee MJ, Palczewska G, Marsili S, Tesar PJ, Palczewski K, Takahashi M, Maeda A.

Retinal pigmented epithelial cells obtained from human induced pluripotent stem cells possess functional visual cycle enzymes in vitro and in vivo.

J Biol Chem. 2013 Nov 29;288(48):34484-93. doi: 10.1074/jbc.M113.518571. Epub 2013 Oct 15.

Link to Publication: Click Here

Factor DC, Najm FJ, Tesar PJ.

Generation and characterization of epiblast stem cells from blastocyst-stage mouse embryos.

Methods Mol Biol. 2013;1074:1-13. doi: 10.1007/978-1-62703-628-3_1.

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Najm FJ, Lager AM, Zaremba A, Wyatt K, Caprariello AV, Factor DC, Karl RT, Maeda T, Miller RH, Tesar PJ

Transcription factor-mediated reprogramming of fibroblasts to expandable, myelinogenic oligodendrocyte progenitor cells

Nat Biotechnol. 2013 Apr 14. doi: 10.1038/nbt.2561. [Epub ahead of print]

Link to Publication: Click Here

Park KS, Cha Y, Kim CH, Ahn HJ, Kim D, Ko S, Kim KH, Chang MY, Ko JH, Noh YS, Han YM, Kim J, Song J, Kim JY, Tesar PJ, Lanza R, Lee KA, Kim KS

Transcription elongation factor Tcea3 regulates the pluripotent differentiation potential of mouse embryonic stem cells via the Lefty1-Nodal-Smad2 pathway

Stem Cells. 2013 Feb;31(2):282-92. doi: 10.1002/stem.1284

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Mallon BS, Chenoweth JG, Johnson KR, Hamilton RS, Tesar PJ, Yavatkar AS, Tyson LJ, Park K, Chen KG, Fann YC, McKay RD

StemCellDB: the human pluripotent stem cell database at the National Institutes of Health

Stem Cell Res. 2013 Jan;10(1):57-66. doi: 10.1016/j.scr.2012.09.002

Link to Publication: Click Here
2012 2012

Iwafuchi-Doi M, Matsuda K, Murakami K, Niwa H, Tesar PJ, Aruga J, Matsuo I, Kondoh H

Transcriptional regulatory networks in epiblast cells and during anterior neural plate development as modeled in epiblast stem cells

Development. 2012 Nov;139(21):3926-37. doi: 10.1242/dev.085936

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Song J, Saha S, Gokulrangan G, Tesar PJ, Ewing RM

DNA and Chromatin Modification Networks Distinguish Stem Cell Pluripotent Ground States

Mol Cell Proteomics. 2012 Jul 22. [Epub ahead of print]

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Nelson VR, Heaney JD, Tesar PJ, Davidson NO, Nadeau JH

Transgenerational epigenetic effects of the Apobec1 cytidine deaminase deficiency on testicular germ cell tumor susceptibility and embryonic viability

Proc Natl Acad Sci U S A. 2012 Aug 24. [Epub ahead of print]

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Akhtar-Zaidi B, Cowper-Sal Lari R, Corradin O, Saiakhova A, Bartels CF, Balasubramanian D, Myeroff L, Lutterbaugh J, Jarrar A, Kalady MF, Willis J, Moore JH, Tesar PJ, Laframboise T, Markowitz S, Lupien M, Scacheri PC

Epigenomic Enhancer Profiling Defines a Signature of Colon Cancer

Science. 2012 Apr 12. [Epub ahead of print]

Link to Publication: Click Here

De Los Angeles A, Loh YH, Tesar PJ, Daley GQ

Accessing naïve human pluripotency

Curr Opin Genet Dev. 2012 Mar 29. [Epub ahead of print]

Link to Publication: Click Here
2011 2011

Miller RH, Tesar PJ

Tracking down the human myelinating cell

Nat Biotechnol; 2011, Oct 13; 29(10):881-3

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Hyun I, Tesar P

Stem cells: Cloning advance calls for careful regulation

Nature; 2011, Oct 5; 478(7367):36-7

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Najm FJ, Zaremba A, Caprariello AV, Nayak S, Freundt EC, Scacheri PC, Miller RH, Tesar PJ

Rapid and robust generation of functional oligodendrocyte progenitor cells from epiblast stem cells

Nat Methods; 2011, Sep 25

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Zentner GE, Tesar PJ, Scacheri PC

Epigenetic signatures distinguish multiple classes of enhancers with distinct cellular functions

Genome Res; 2011, Aug 1

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Najm FJ, Chenoweth JG, Anderson PD, Nadeau JH, Redline RW, McKay RD, Tesar PJ

Isolation of epiblast stem cells from preimplantation mouse embryos

Cell Stem Cell; 2011, Mar 4; 8(3):318-25

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2010 2010

Chenoweth JG, Tesar PJ

Isolation and maintenance of mouse epiblast stem cells

Methods Mol Biol; 2010, Dec 31; 636:25-44

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Di Stefano B, Buecker C, Ungaro F, Prigione A, Chen HH, Welling M, Eijpe M, Mostoslavsky G, Tesar P, Adjaye J, Geijsen N, Broccoli V

An ES-like pluripotent state in FGF-dependent murine iPS cells

PLoS One; 2010, Dec 30; 5(12):e16092

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Zentner GE, Hurd EA, Schnetz MP, Handoko L, Wang C, Wang Z, Wei C, Tesar PJ, Hatzoglou M, Martin DM, Scacheri PC

CHD7 functions in the nucleolus as a positive regulator of ribosomal RNA biogenesis

Hum Mol Genet; 2010, Sep 15, 19(18):3491-501

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Schnetz MP, Handoko L, Akhtar-Zaidi B, Bartels CF, Pereira CF, Fisher AG, Adams DJ, Flicek P, Crawford GE, Laframboise T, Tesar P, Wei CL, Scacheri PC

CHD7 targets active gene enhancer elements to modulate ES cell-specific gene expression

PLoS Genet; 2010, Jul 15; 6(7):e1001023

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Hemberger M, Udayashankar R, Tesar P, Moore H, Burton GJ

ELF5-enforced transcriptional networks define an epigenetically regulated trophoblast stem cell compartment in the human placenta

Hum Mol Genet; 2010, Jun 15

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Chenoweth JG, McKay RD, Tesar PJ

Epiblast stem cells contribute new insight into pluripotency and gastrulation

Dev Growth Differ; 2010, Apr 1

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Greber B, Wu G, Bernemann C, Joo JY, Han DW, Ko K, Tapia N, Sabour D, Sterneckert J, Tesar P, Schöler HR

Conserved and Divergent Roles of FGF Signaling in Mouse Epiblast Stem Cells and Human Embryonic Stem Cells

Cell Stem Cell; 2010, Mar 5; 6(3):215-226

Link to Publication: Click Here
2009 2009

Anderson PD, Nelson VR, Tesar PJ, Nadeau JH

Genetic Factors on Mouse Chromosome 18 Affecting Susceptibility to Testicular Germ Cell Tumors and Permissiveness to Embryonic Stem Cell Derivation

Cancer Res; 2009, Dec 1

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2008 2008

Chou YF, Chen HH, Eijpe M, Yabuuchi A, Chenoweth JG, Tesar P, Lu J, McKay RD, Geijsen N

The growth factor environment defines distinct pluripotent ground states in novel blastocyst-derived stem cells

Cell; 2008, Oct 31; 135(3):449-61

Link to Publication: Click Here
2007 2007

Xi H, Shulha HP, Lin JM, Vales TR, Fu Y, Bodine DM, McKay RD, Chenoweth JG, Tesar PJ, Furey TS, Ren B, Weng Z, Crawford GE

Identification and characterization of cell type-specific and ubiquitous chromatin regulatory structures in the human genome

PLoS Genet;2007, Aug 28; 3(8):e136

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Tesar PJ, Chenoweth JG, Brook FA, Davies TJ, Evans EP, Mack DL, Gardner RL, McKay RD

New cell lines from mouse epiblast share defining features with human embryonic stem cells

Nature; 2007, Jul 12; 448(7150):196-9

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2006 2006

Mackay DL, Tesar PJ, Liang LN, Haynesworth SE

Characterizing medullary and human mesenchymal stem cell-derived adipocytes

J Cell Physiol;2006 Jun 2; 207(3):722-8

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2005 2005

Tesar PJ

Derivation of germ-line-competent embryonic stem cell lines from preblastocyst mouse embryos

Proc Natl Acad Sci U S A; 2005, Jun 7; 102(23):8239-44

Link to Publication: Click Here